Easiest way

Option Explicit
Sub OverUnder()
Dim R As Long, B As Long, G As Long, O As Long
Dim i As Long
Dim s As String
With ActiveSheet.Cells(1, 1).CurrentRegion
For i = 3 To .Rows.Count
R = 0
B = 0
G = 0
O = 0
s = LCase(.Cells(i, 1).Value)
If InStr(s, "red") > 0 Then R = R + 1
If InStr(s, "blue") > 0 Then B = B + 1
If InStr(s, "green") > 0 Then G = G + 1
If InStr(s, "orange") > 0 Then O = O + 1
s = LCase(.Cells(i, 2).Value)
If InStr(s, "red") > 0 Then R = R - 1
If InStr(s, "blue") > 0 Then B = B - 1
If InStr(s, "green") > 0 Then G = G - 1
If InStr(s, "orange") > 0 Then O = O - 1
.Cells(i, 3).Resize(1, 8).Value = 0
If R > 0 Then
.Cells(i, 3) = R
ElseIf R < 0 Then
.Cells(i, 4) = -R
End If
If G > 0 Then
.Cells(i, 5) = G
ElseIf G < 0 Then
.Cells(i, 6) = -G
End If
If B > 0 Then
.Cells(i, 7) = B
ElseIf B < 0 Then
.Cells(i, 8) = -B
End If
If O > 0 Then
.Cells(i, 9) = O
ElseIf O < 0 Then
.Cells(i, 10) = -O
End If
Next i
End With
End Sub