you may try this, paste this on a Module:
on Sheet1, add this code:Public Sub mySub() Dim i As Integer Dim rng As Range With Sheet1 For i = 1 To .Range("a1").SpecialCells(xlCellTypeLastCell).Row Set rng = .Range("e" & i) If WorksheetFunction.CountIf(Sheet2.Range("a:a"), rng) = 0 Then rng.Interior.Color = vbRed End If Next End With End Sub
Private Sub Worksheet_Change(ByVal Target As Range) Call mySub End Sub