You'd better work in memory than in sheets/ranges/cells

Sub test2() 
  with ActiveSheet
    .Cells(1, 1).Value = 111 
    .Cells(2, 1).Value = 222 
    .Cells(3, 1).Value = 333 
    .Cells(4, 1).Value = 444 
    .Cells(1, 2).Value = 555 
    .Cells(2, 2).Value = 666 
    .Cells(3, 2).Value = 777 
    .Cells(4, 2).Value = 888 
   end with
   
      sn = ActiveSheet.Cells(1, 1).CurrentRegion 
     
      For j=1 To ubound(sn) 
    MsgBox sn(j,1) & vbtab & sn(j,2) 
  Next
End Sub